The cliché is that creativity and depression go hand-in-hand. Like many clichés, this one is quite true. But creators are not necessarily afflicted with some biological disease or psychological disorder that causes them to experience depression at the alarming rates that we see. They experience depression simply because they are caught up in a struggle to make life seem meaningful to them. People for whom meaning is no problem are less likely to experience depression. But for creators, losses of meaning and doubts about life’s meaningfulness are persistent problems—even the root causes of their depression.“
Eric Maisel, from The Van Gogh Blues: The Creative Person’s Path through Depression (New World Library, 2007)